Pellets are superior to oral and topical hormone therapy with respect to relief of menopausal symptoms. Estradiol and testosterone implants have consistently been shown to improve:
- sex drive
- hot flashes
- vaginal dryness
Hormone replacement therapy with estradiol and testosterone implants is superior to oral and topical (both the patch and gel) hormone replacement therapy for bone density. The pellets not only prevent bone loss but also actually increase bone density.
Testosterone implants in women have been shown to improve lethargy, depression, cognitive function, loss of libido, and hot flashes without attenuating the beneficial effects of estradiol on cardiac and lipid profiles. Testosterone delivered by subcutaneous implants does not increase the risk of breast cancer as does oral, synthetic methyl-testosterone.
Pellets do not have the same risk of breast cancer as the synthetic progestins or synthetic Methyltestosterone. In fact, studies show a reduction in the incidence of breast cancer with the implantation of testosterone pellets, with or without estradiol pellets. Hormone replacement therapy with a 20 mg estradiol pellet has been shown to have a lower risk of breast cancer than patients without hormone replacement therapy.
Even after over 20 years of therapy with hormone implants, the risk of breast cancer is not increased. In breast cancer survivors, hormone replacement therapy with pellet implantation does not increase the risk of cancer recurrence or death as does estrogen in combination with the synthetic progestins.
Hormone replacement therapy with pellet implantation has an extremely low incidence of side effects and high compliance rate. It has been shown to be extremely effective in the treatment of migraine headaches.
Testosterone replacement therapy in men with subcutaneous implants (pellets) has been shown to be extremely effective, convenient and safe.